Stars Portia de Rossi and Jerry O’Connell are also the part of Munsters reboot.
"It's much more elegant," Izzard - who will play Grandpa Munster - told Entertainment Weekly. "It's twisted-dramatic that does hit comedic somewhere in there."
The comedian and actor encouraged viewers to "watch and see the humanity within monsters. They can see themselves reflected [back]. These sick and twisted parts… are part of all of our minds, and that is our life's work to control those things or push them aside."
The reboot, which has also been retitled as Mockingbird Lane, has been devised by Pushing Daisies creator Bryan Fuller, and also stars Donnie Darko’s Beth Grant and 30 Rock’s Cheyenne Jackson.